Lupus Biomarkers and Treatment Center
Center for Lupus Research
This program develops tests and maps immune pathways to help children and adults with lupus get more personalized care.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11182490 on NIH RePORTER |
What this research studies
If you join, researchers will collect blood and other samples from children and adults with systemic lupus to study immune and blood cells. They use advanced single-cell genetic and epigenetic profiling and other lab assays to find the molecules and pathways that drive disease and treatment failure. The team is following a new lead that mitochondrial bits from red blood cells may trigger inflammation in some patients. Their work aims to create tests that track these pathways and help match patients to better therapies.
Who could benefit from this research
Good fit: People of any age with systemic lupus erythematosus, especially those with active disease or who have not responded well to standard therapies, would be the best candidates.
Not a fit: People without lupus or those unwilling to provide blood samples and clinical information are unlikely to receive direct benefit from this program.
Why it matters
Potential benefit: Could lead to lab tests that predict who will respond to treatments and enable more personalized lupus care.
How similar studies have performed: Previous lupus research has found useful biomarkers, but the focus on red blood cell–derived mitochondrial nucleic acids combined with deep single-cell profiling is a newer approach with limited prior testing.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Pascual, Maria Virginia — Weill Medical Coll of Cornell Univ
- Study coordinator: Pascual, Maria Virginia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.