Lung cancer risk created by genes and environment across diverse populations
Official title: Project 1: Smoking, environmental and genomic factors in lung cancer and managing risk
Funded at University of New Mexico Health Scis Ctr · NIH-11189788 · Data updated 2026-11-12
A multi-ethnic study aims to understand how genetic and environmental factors together influence lung cancer risk and prevention.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of New Mexico Health Scis Ctr NIH-funded |
| Lab location | 1 site (Albuquerque, United States) |
| Project start | August 1, 2017 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $454,240 |
| NIH project number | 5U19CA203654-10 |
| Project ID | NIH-11189788 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals across diverse ancestries, including African and Asian descent, potentially at risk for lung cancer or with related family risk.
✕Less likely to help
People without risk factors or those not represented in the study populations may see limited direct benefit.
What this research studies
This project uses large-scale genetic data and environmental information to study why lung cancer affects people differently across ancestries. Researchers will genotype diverse participants and combine data with whole-genome sequencing to build the world’s largest resource for lung cancer susceptibility variants. They will also analyze how environmental exposures and host factors interact with genetics to shape lung cancer risk, aiming to translate findings into better prevention for diverse communities.
Why it matters
Potential benefit: If successful, findings could lead to more personalized lung cancer prevention strategies that consider ancestry and environment.
How similar studies have gone: Previous GWAS have identified risk loci, but this project extends discovery across multiple ancestries, which is ongoing and promising.
Where this research is happening
-
University of New Mexico Health Scis Ctr
Albuquerque, United States Active
Researchers
- Principal investigator: Amos, Christopher I. — University of New Mexico Health Scis Ctr
- Study coordinator: Amos, Christopher I.
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This project uses a personalized risk profile to help current and former smokers—particularly underserved and African American patients—get lung cancer screening and stop smoking.
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This project looks for genetic, biochemical, and epigenetic reasons why cigarette smoking leads to different lung cancer risks in people from several racial and ethnic groups.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.