Lung and blood immune cell collection for genetic analysis
Patient Sampling and Genomics Core
This project collects immune cells from the lungs and blood of people with ARDS and severe lung infections to look at their genes and activity.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project ID | NIH-11172566 on NIH RePORTER |
What this research studies
If I join, clinicians will collect fluid from my lungs using a non‑bronchoscopic lavage and draw blood to isolate immune cells. My clinical information will be entered into a secure database and my cells will be analyzed with techniques like flow cytometry, bulk RNA sequencing, and single‑cell RNA sequencing. Some participants will provide samples over time so researchers can track immune changes during illness. The team will use bioinformatics to link cell behavior and gene activity to how sick someone becomes.
Who could benefit from this research
Good fit: Ideal candidates are adults with sepsis, pneumonia, or other causes of acute respiratory distress who are receiving mechanical ventilation and can safely undergo non‑bronchoscopic lung sampling.
Not a fit: Patients who are not critically ill, who cannot safely undergo lung sampling, or who do not have ARDS are unlikely to be included or directly benefit.
Why it matters
Potential benefit: If successful, this work could identify immune cell signatures that help predict outcomes or guide new treatments for ARDS.
How similar studies have performed: Similar bronchoalveolar and blood immune cell sequencing studies have yielded useful insights in lung injury, but combining non‑bronchoscopic longitudinal sampling with single‑cell genomics is a relatively new approach.
Where this research is happening
Chicago, UNITED STATES
- University of Illinois at Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Dudek, Steven M — University of Illinois at Chicago
- Study coordinator: Dudek, Steven M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.