LOX-1's role in protecting lungs during infection
LOX-1 as a protective countermeasure in response to lung infection
This work looks at whether a protein called LOX‑1 helps reduce harmful inflammation and protect people who develop pneumonia or ARDS.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11095756 on NIH RePORTER |
What this research studies
If you took part, researchers would study lung fluid and tissue from people with pneumonia and also use mouse models of lung infection to learn where LOX‑1 appears. They will focus on immune cells in the air spaces, like alveolar macrophages and neutrophils, and change LOX‑1 levels in mice to see how inflammation and lung damage change. The team will compare findings from human samples and mice to see if LOX‑1 helps keep lung tissue intact during infection and could point to new treatment approaches.
Who could benefit from this research
Good fit: Adults with pneumonia or ARDS who can provide lung fluid or tissue samples, or patients hospitalized with severe lung infections at participating centers, would be the most relevant candidates.
Not a fit: People without active lung infection or with unrelated chronic lung conditions are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this could point to new ways to limit damaging inflammation in pneumonia and ARDS, potentially reducing lung injury and improving recovery.
How similar studies have performed: LOX‑1 has known roles in cardiovascular disease, but using LOX‑1 biology to protect lungs during infection is a new and largely untested approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Quinton, Lee — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Quinton, Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.