Lowering cholesterol to improve immune response in prostate cancer
Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer
['FUNDING_R01'] · CEDARS-SINAI MEDICAL CENTER · NIH-10933005
This study is looking at whether lowering cholesterol can help boost the immune system's ability to fight prostate cancer, and it involves both animal tests and human trials to see how this change affects important immune cells.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CEDARS-SINAI MEDICAL CENTER (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-10933005 on ClinicalTrials.gov |
What this research studies
This research investigates how lowering cholesterol levels may enhance the immune response against prostate cancer. It builds on previous findings that suggest a link between cholesterol-lowering therapies and reduced prostate cancer mortality. The study will involve both animal models and human clinical trials to explore how cholesterol reduction affects immune cells, particularly CD8+ T cells, which play a crucial role in fighting cancer. By understanding these mechanisms, the research aims to identify new strategies for improving cancer treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are prostate cancer patients who are undergoing treatment and may benefit from cholesterol-lowering interventions.
Not a fit: Patients with advanced metastatic prostate cancer who are not candidates for cholesterol-lowering therapies may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to fight prostate cancer.
How similar studies have performed: Previous studies have shown promising results linking cholesterol-lowering therapies with improved cancer outcomes, suggesting that this approach may be effective.
Where this research is happening
LOS ANGELES, UNITED STATES
- CEDARS-SINAI MEDICAL CENTER — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, HYUNG L — CEDARS-SINAI MEDICAL CENTER
- Study coordinator: KIM, HYUNG L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Atherosclerotic Cardiovascular Disease