Lowering cholesterol to improve immune response in prostate cancer
Official title: Intensive cholesterol-lowering intervention and anti-tumor immunity modeled in prostate cancer
Funded at Cedars-Sinai Medical Center · NIH-10933005 · Data updated 2026-11-12
This study is looking at whether lowering cholesterol can help boost the immune system's ability to fight prostate cancer, and it involves both animal tests and human trials to see how this change affects important immune cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 21, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $657,403 |
| NIH project number | 5R01CA280060-02 |
| Project ID | NIH-10933005 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are prostate cancer patients who are undergoing treatment and may benefit from cholesterol-lowering interventions.
✕Less likely to help
Patients with advanced metastatic prostate cancer who are not candidates for cholesterol-lowering therapies may not receive benefit from this research.
What this research studies
This research investigates how lowering cholesterol levels may enhance the immune response against prostate cancer. It builds on previous findings that suggest a link between cholesterol-lowering therapies and reduced prostate cancer mortality. The study will involve both animal models and human clinical trials to explore how cholesterol reduction affects immune cells, particularly CD8+ T cells, which play a crucial role in fighting cancer. By understanding these mechanisms, the research aims to identify new strategies for improving cancer treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that enhance the immune system's ability to fight prostate cancer.
How similar studies have gone: Previous studies have shown promising results linking cholesterol-lowering therapies with improved cancer outcomes, suggesting that this approach may be effective.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Kim, Hyung L — Cedars-Sinai Medical Center
- Study coordinator: Kim, Hyung L
Related research
Other NIH-funded projects on the same topics.
-
Cardiovascular risk planning and reduction for men with prostate cancer
A program to better predict and reduce heart disease risk in men treated for prostate cancer, especially older patients.
-
Effects of ADT on motivation and emotion in prostate cancer patients
This project looks at how androgen deprivation therapy may affect motivation and mood over time in men with prostate cancer.
-
Causal Protein Markers to Understand and Predict Prostate Cancer Risk in Africans and Europeans
A cancer research project looking at proteins linked to prostate cancer to better understand why it happens and how risk differs between African and European populations.
-
Ethical multimodal AI platform to improve prostate cancer detection with ultrasound
A patient-friendly AI system uses ultrasound and MRI information to help doctors better find prostate cancer, aiming to improve accuracy and access.
-
Characterizing epigenetic targets in prostate cancer to help AR-driven cancer
A research project at MD Anderson aims to understand how epigenetic factors shape androgen receptor signaling in prostate cancer to find new ways to treat resistant forms of the disease.
-
AR and RNA-binding in prostate cancer resistance
A cancer research grant exploring how the androgen receptor’s interaction with RNA may drive treatment resistance in prostate cancer, with potential to guide new therapies.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.