Long-term heart and metabolic health in women with HIV on a DTG-based ART
Official title: Longitudinal Assessment of Cardiometabolic Outcomes in Women Living with HIV on Dolutegravir-Based Antiretroviral Therapy Across the Lifespan
Funded at Johns Hopkins University · NIH-11605887 · Data updated 2026-11-12
This study follows women with HIV over five years to compare how a dolutegravir-based therapy versus an alternative regimen affects heart and metabolic health across the lifespan.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 5, 2026 |
| Project end | May 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $198,720 |
| NIH project number | 3R01HL182418-01A1S2 |
| Project ID | NIH-11605887 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are women living with HIV who are starting or currently on DTG-based or ATV/r-based ART and are willing to be followed for five years.
✕Less likely to help
This study may not directly benefit women who are not living with HIV or who are not on DTG- or ATV/r-based regimens.
What this research studies
Women living with HIV will be enrolled in a five-year prospective cohort at two Nigerian sites to compare cardiometabolic outcomes between DTG-based ART and ATV/r-based ART. The study uses regular clinical assessments such as lipid panels, glucose and insulin tests, vascular function measurements, and heart performance indices to understand potential long-term risks. Researchers will analyze data across reproductive life stages—from pre-menopause to pregnancy to post-menopause—to see how hormonal changes interact with ART. The goal is to identify whether DTG-based therapy leads to more cardiometabolic complications and who might be most at risk. Results could guide personalized ART choices to protect heart and metabolic health in WHIV.
Why it matters
Potential benefit: If successful, findings could inform safer, tailored ART choices for women with HIV to reduce future heart and metabolic problems.
How similar studies have gone: Previous research suggests ART regimens can affect metabolic health, but long-term, life-stage–specific data in WHIV are limited and this study would add novel insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Eke, Ahizechukwu C. — Johns Hopkins University
- Study coordinator: Eke, Ahizechukwu C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.