Localized EDTA Therapy to Remove Calcification in PAD
Official title: Localized Chelation Therapy for Removing Calcification in PAD
Funded at University of Nebraska Omaha · NIH-11408754 · Data updated 2026-11-12
A new, targeted EDTA treatment delivered directly to calcified leg arteries aims to reduce calcium buildup and improve blood flow for people with peripheral artery disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Omaha NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project start | September 5, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $652,762 |
| NIH project number | 5R01HL180371-02 |
| Project ID | NIH-11408754 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with peripheral artery disease and arterial calcification who may benefit from targeted EDTA chelation therapy.
✕Less likely to help
Patients without significant lower-extremity arterial calcification or those not suitable for catheter-based delivery may not benefit.
What this research studies
This project tests a novel approach to remove arterial calcium by delivering EDTA directly into calcified leg arteries using a microneedle catheter. Researchers will study how well this local delivery reduces calcification, lowers inflammation, and enhances limb movement and blood flow, while avoiding systemic side effects. They will analyze human donor arteries and a large animal model to understand how the treatment distributes, its tissue effects, and the timing and dose needed. The study builds on extensive experience with calcified human arteries and aims to translate findings into safer, more effective care for PAD patients.
Why it matters
Potential benefit: If successful, this approach could lessen amputation risk and improve mobility for PAD patients by directly targeting arterial calcification.
How similar studies have gone: Prior work has explored EDTA chelation broadly, but this project uses a targeted, local delivery method in human tissues and a preclinical large-animal model, representing a novel approach with promising potential.
Where this research is happening
-
University of Nebraska Omaha
Omaha, United States Active
Researchers
- Principal investigator: Kamenskiy, Alexey — University of Nebraska Omaha
- Study coordinator: Kamenskiy, Alexey
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.