Living tumor model and tissue bank for diverse cancers
PDX Core
['FUNDING_OTHER'] · VIRGINIA COMMONWEALTH UNIVERSITY · NIH-11128348
Creating and sharing living tumor models made from patients—especially people from underrepresented racial and ethnic groups with advanced cancer—to help create better treatments.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VIRGINIA COMMONWEALTH UNIVERSITY (nih funded) |
| Locations | 1 site (RICHMOND, UNITED STATES) |
| Trial ID | NIH-11128348 on ClinicalTrials.gov |
What this research studies
This project collects patients' tumor tissue and grows it as living models (patient-derived xenografts) that preserve the cancer's original biology. The PDX Core will expand and store these tumors, link them to clinical, genomic, and ancestry information, and maintain a searchable specimen database. The effort prioritizes increasing samples from Black and other underrepresented groups and from advanced or aggressive cancers. Researchers in the network will use the banked models to test therapies and study differences in disease behavior by ancestry.
Who could benefit from this research
Good fit: Ideal candidates are people with advanced or treatment-resistant tumors who can provide excess tumor tissue from surgery or biopsy, especially patients from Black and other underrepresented racial or ethnic groups.
Not a fit: Patients without available tumor tissue, those with early-stage cancers who cannot provide samples, or those seeking direct personal treatment benefit are unlikely to gain direct benefit from participating.
Why it matters
Potential benefit: If successful, this resource could speed development of treatments that are more effective for cancers common or more aggressive in underrepresented populations.
How similar studies have performed: Patient-derived xenografts are a well-established method for modeling human tumors, but assembling a large, ancestry-linked PDX collection focused on minority groups is less common.
Where this research is happening
RICHMOND, UNITED STATES
- VIRGINIA COMMONWEALTH UNIVERSITY — RICHMOND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KOBLINSKI, JENNIFER E — VIRGINIA COMMONWEALTH UNIVERSITY
- Study coordinator: KOBLINSKI, JENNIFER E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Advanced Cancer