Liver damage caused by herbal and dietary supplements
Herbal and Dietary Supplement Induced Liver Injury in the U.S.
This project enrolls people whose livers were harmed after taking herbal or dietary supplements to find the causes and improve how these injuries are detected and tracked.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Thomas Jefferson University NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11180470 on NIH RePORTER |
What this research studies
You can join if you had liver injury after taking a drug or a herbal/dietary supplement, whether it happened recently or in the past. The team collects your medical records, blood and other samples, and the actual supplement products you used, and stores them in a central repository. Partner labs (NCNPR, NTP, and the Botanical Safety Consortium) will chemically analyze products and run lab tests to look for harmful ingredients and possible injury mechanisms. Researchers will also try a new causality scoring tool (RECAM) and work to increase enrollment of people from under-represented groups.
Who could benefit from this research
Good fit: Ideal participants are people who have experienced liver injury suspected to be caused by an herbal or dietary supplement or a drug and who can provide medical records, samples, and implicated product(s).
Not a fit: People without a history of liver injury from supplements or drugs are unlikely to receive direct benefit from this project.
Why it matters
Potential benefit: If successful, this work could help identify dangerous supplement ingredients and improve diagnosis and prevention of supplement-related liver injury.
How similar studies have performed: Previous DILIN work has already identified many supplement-related liver injuries, and this effort builds on that experience by adding product chemical analysis and validation of a new causality tool.
Where this research is happening
Philadelphia, United States
- Thomas Jefferson University — Philadelphia, United States (Active)
Researchers
- Principal investigator: Halegoua-Demarzio, Dina — Thomas Jefferson University
- Study coordinator: Halegoua-Demarzio, Dina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.