Lipin-1 helps macrophages resolve inflammation in atherosclerosis
Official title: Lipin-1 transcriptional coregulatory activity promotes macrophage pro-resolving response
Funded at Louisiana State Univ Hsc Shreveport · NIH-11384481 · Data updated 2026-11-12
This grant explores how Lipin-1 helps immune cells resolve inflammation in artery disease to reduce heart risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $550,760 |
| NIH project number | 5R01HL163106-04 |
| Project ID | NIH-11384481 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with atherosclerotic cardiovascular disease or related risk factors who could benefit from therapies that promote inflammation resolution.
✕Less likely to help
People whose disease is driven by factors beyond inflammation resolution may see limited benefit.
What this research studies
In people with atherosclerotic cardiovascular disease, chronic inflammation fuels plaque buildup. The research focuses on macrophages and how Lipin-1 supports their ability to clear dead cells and secrete anti-inflammatory signals. It looks at how lipid processing inside these cells influences inflammation and plaque regression, aiming to uncover new ways to promote healing without raising infection risk. The work combines biological studies with experiments that could point toward new therapies that enhance inflammation resolution in arteries.
Why it matters
Potential benefit: If successful, the work could lead to therapies that help the body resolve artery inflammation more effectively, potentially reducing plaque progression and heart risk.
How similar studies have gone: Previous work suggests macrophage lipid metabolism influences inflammation resolution and atherosclerosis, with promising but early results.
Where this research is happening
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Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Woolard, Matthew Dale — Louisiana State Univ Hsc Shreveport
- Study coordinator: Woolard, Matthew Dale
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.