Left Atrial Appendage Occlusion in Older Adults with Atrial Fibrillation and Frailty
Official title: Utilization and Clinical Outcomes of Left Atrial Appendage Occlusion in Older Adults with Atrial Fibrillation and Frailty
Funded at Hebrew Rehabilitation Center for Aged · NIH-11310178 · Data updated 2026-11-12
This study looks at how often a heart procedure called left atrial appendage occlusion is used and what outcomes occur in older adults with atrial fibrillation and frailty.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hebrew Rehabilitation Center for Aged NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 1, 2024 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $699,392 |
| NIH project number | 5R01HL175560-03 |
| Project ID | NIH-11310178 on NIH RePORTER |
Who could benefit from this research
✓Could help
Older adults (65+) with atrial fibrillation and frailty who are considerered for or have received left atrial appendage occlusion.
✕Less likely to help
Patients without atrial fibrillation or without frailty, or those not candidates for LAAO, may not benefit from this research.
What this research studies
This project focuses on older adults, 65 and older, who have atrial fibrillation and frailty. It will compare the use of left atrial appendage occlusion to other treatment options and examine real-world outcomes. The goal is to understand how this procedure affects safety and effectiveness in a population at higher risk for bleeding and stroke. The findings could help doctors and patients choose care plans that balance stroke prevention with bleeding risk.
Why it matters
Potential benefit: If successful, the study could clarify when LAAO is most beneficial for frail older adults and guide personalized treatment decisions.
How similar studies have gone: There is evidence from trials in other populations, but effectiveness in frail older adults remains uncertain, making this study timely and potentially practice-changing.
Where this research is happening
-
Hebrew Rehabilitation Center for Aged
Boston, United States Active
Researchers
- Principal investigator: Ko, Darae — Hebrew Rehabilitation Center for Aged
- Study coordinator: Ko, Darae
Related research
Other NIH-funded projects on the same topics.
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Evaluating a procedure to prevent strokes in older adults with atrial fibrillation and frailty
This study is looking at whether a procedure called left atrial appendage occlusion (LAAO) can help prevent strokes in older adults with atrial fibrillation who can't safely take blood thinners, to see if it's a good and safe option for them.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.