Knowledge-guided multi-omics and transfer learning for emerging bacterial infections
Official title: Knowledge-Guided Multi-Omics Integration and Transfer Learning for Emerging Infections
Funded at Michigan State University · NIH-11439350 · Data updated 2026-11-12
A patient-facing, learn-from-data project aims to improve tools that diagnose and predict outcomes for melioidosis, a serious infection caused by Burkholderia pseudomallei.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | September 17, 2026 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $239,917 |
| NIH project number | 1R21AI203026-01 |
| Project ID | NIH-11439350 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with suspected or confirmed Burkholderia pseudomallei infection or melioidosis may benefit from improved diagnostic and prognostic models.
✕Less likely to help
Patients without access to the healthcare settings where melioidosis is recognized or those not aligned with the study’s data framework may see no direct benefit.
What this research studies
This project builds advanced machine learning methods that connect biological pathways to disease signals using multi-omics data from infected patients. It focuses on small-sample studies of emerging infections and seeks to make predictions more reliable and explanations more understandable. It also uses information learned from larger clinical datasets to boost accuracy in a smaller, more complex dataset, potentially helping clinicians make better diagnoses and prognoses for melioidosis.
Why it matters
Potential benefit: If successful, it could lead to better diagnostic and prognostic tools for melioidosis and related bacterial infections.
How similar studies have gone: Previous studies show that pathway-guided models and transfer learning can improve predictions in complex diseases, but application to melioidosis or similar infections is still developing.
Where this research is happening
-
Michigan State University
East Lansing, United States Active
Researchers
- Principal investigator: Xia, Lu — Michigan State University
- Study coordinator: Xia, Lu
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.