Investigating ways to prevent kidney injury caused by cisplatin chemotherapy
Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney Injury
This study is looking at how to protect your kidneys from damage while getting cisplatin, a common chemotherapy drug, by testing four different medications to see which one works best for preventing kidney problems in cancer patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10992679 on NIH RePORTER |
What this research studies
This research focuses on understanding and preventing acute kidney injury (AKI) that can occur in patients receiving cisplatin, a common chemotherapy drug. The study will evaluate the effects of four different medications—IV magnesium, mannitol, metformin, and statins—on the incidence of cisplatin-associated AKI. By analyzing data from over 45,000 patients and conducting a randomized clinical trial with mesothelioma patients, the research aims to identify effective strategies to protect the kidneys during cancer treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults receiving cisplatin chemotherapy, particularly those at risk for acute kidney injury.
Not a fit: Patients who are not receiving cisplatin or those with pre-existing severe kidney conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney health and reduced complications for cancer patients undergoing cisplatin treatment.
How similar studies have performed: Previous research has shown promising results in using IV magnesium to protect against kidney injury, indicating potential success for this approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Gupta, Shruti — Brigham and Women's Hospital
- Study coordinator: Gupta, Shruti
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.