Investigating ways to prevent acute lung injury
Official title: Targeting mechanisms activating ion-channel for preventing acute lung injury
Funded at University of Illinois at Chicago · NIH-11007224 · Data updated 2026-11-12
This study is looking at how a specific part of lung cells might help heal injuries caused by infections, and it’s for people dealing with serious breathing problems like acute lung injury and acute respiratory distress syndrome.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Illinois at Chicago NIH-funded |
| Lab location | 1 site (Chicago, UNITED STATES) |
| Project start | March 15, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $539,663 |
| NIH project number | 5R01HL165263-03 |
| Project ID | NIH-11007224 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing acute lung injury or ARDS, particularly those with a bacterial or viral infection.
✕Less likely to help
Patients with chronic lung conditions or those not experiencing acute lung injury may not benefit from this research.
What this research studies
This research focuses on understanding how certain ion channels in the lungs contribute to acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), particularly during infections. The team is exploring a specific mutation in the TRPC6 ion channel that may help shift the lung's response from inflammation to regeneration. By blocking this channel's activity, they aim to promote healing in lung cells, which could lead to better outcomes for patients suffering from these serious conditions. The approach includes advanced techniques like nuclear magnetic resonance to study the channel's behavior.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and recovery for patients with acute lung injury and ARDS.
How similar studies have gone: Other research has shown promise in targeting ion channels for therapeutic purposes, suggesting that this approach could lead to meaningful advancements in treating lung injuries.
Where this research is happening
-
University of Illinois at Chicago
Chicago, United States Active
Researchers
- Principal investigator: Mehta, Dolly — University of Illinois at Chicago
- Study coordinator: Mehta, Dolly
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.