Investigating ways to improve heart transplant acceptance using innovative therapies
Official title: Using trained immunity-inhibiting nanobiologics to achieve tolerance of heart allografts in non-human primates
Funded at Icahn School of Medicine at Mount Sinai · NIH-11064098 · Data updated 2026-11-12
This study is looking at new ways to help the body accept heart transplants better by using special treatments, which could eventually lead to improved outcomes for people receiving heart transplants.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $816,856 |
| NIH project number | 5P01AI168258-03 |
| Project ID | NIH-11064098 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are undergoing or are candidates for heart transplantation.
✕Less likely to help
Patients who are not candidates for heart transplantation or those with contraindications for transplant procedures may not benefit from this research.
What this research studies
This research explores how to achieve tolerance of heart transplants in non-human primates by using a combination of advanced therapies. The approach involves understanding the immune response and developing new methods to reduce inflammation and enhance the body's acceptance of transplanted organs. By studying the effects of trained immunity and mixed chimerism, the research aims to find effective alternatives to kidney co-transplantation for improving heart allograft outcomes. Patients may benefit from insights gained that could lead to better transplant acceptance in humans.
Why it matters
Potential benefit: If successful, this research could lead to improved heart transplant outcomes and reduced rejection rates for patients.
How similar studies have gone: Previous research has shown success in achieving kidney allograft tolerance using similar approaches, but this specific application to heart transplants is novel.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Madsen, Joren C — Icahn School of Medicine at Mount Sinai
- Study coordinator: Madsen, Joren C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.