Investigating unique immune cells in inflamed tissues of patients with lupus and rheumatoid arthritis
Origin and function of atypical lymphocyte populations in inflamed tissue in SLE and RA
This study is looking at certain immune cells in people with lupus and rheumatoid arthritis to learn more about how they behave and interact, with the hope of finding better treatments for these conditions.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11064780 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific B cells associated with age and autoimmunity in patients suffering from systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). By analyzing inflamed tissues from the kidneys and joints, the study aims to identify the characteristics, origins, and interactions of these atypical lymphocytes with other immune cells. The goal is to uncover new mechanisms of disease and potential therapeutic targets that could lead to improved treatments for these autoimmune conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or rheumatoid arthritis, particularly those experiencing significant inflammation.
Not a fit: Patients with autoimmune conditions other than lupus or rheumatoid arthritis may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that more effectively target the underlying causes of lupus and rheumatoid arthritis.
How similar studies have performed: Previous research has shown promise in understanding immune cell populations in autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Diamond, Betty — Brigham and Women's Hospital
- Study coordinator: Diamond, Betty
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.