Investigating the use of inhaled nitric oxide to improve outcomes in children with acute respiratory distress syndrome.
Official title: Dead Space and Inhaled Nitric Oxide in Pediatric Acute Respiratory Distress Syndrome
Funded at Children's Hospital of Los Angeles · NIH-10859725 · Data updated 2026-11-12
This study is looking at ways to help doctors better understand and treat children with a serious lung condition called ARDS by finding clues in their routine health data, so they can figure out which kids might respond best to certain treatments and ultimately help them recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hospital of Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | September 20, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $873,736 |
| NIH project number | 1R01HL173488-01 |
| Project ID | NIH-10859725 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who are diagnosed with acute respiratory distress syndrome.
✕Less likely to help
Patients who do not have acute respiratory distress syndrome or are older than 11 years may not benefit from this research.
What this research studies
This research focuses on pediatric acute respiratory distress syndrome (ARDS), a serious condition affecting children that has a high mortality rate. The study aims to identify biological markers that can help differentiate between patients who may benefit from specific therapies and those who may not. By analyzing routine patient monitoring data, such as capnography and blood gases, the researchers will estimate dead space in the lungs, which may provide insights into the underlying causes of ARDS and guide treatment decisions. The ultimate goal is to improve survival rates and treatment effectiveness for children suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for children with ARDS, potentially reducing mortality rates.
How similar studies have gone: Previous studies have shown promise in using biological markers to guide treatment in ARDS, but this specific approach focusing on dead space is relatively novel.
Where this research is happening
-
Children's Hospital of Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Bhalla, Anoopindar — Children's Hospital of Los Angeles
- Study coordinator: Bhalla, Anoopindar
Related research
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A Duke University team is using biomarkers and smart data analysis to detect ARDS early and uncover patterns that predict how patients recover.
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PAR1’s role in lung lymphatics and a new therapy approach for ARDS
This grant explores how the thrombin receptor PAR1 affects lung lymphatics to understand and ultimately reduce lung injury in ARDS patients.
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Dead space and inhaled nitric oxide in pediatric ARDS
This project looks at whether measuring dead space and using inhaled nitric oxide can help improve outcomes for children with acute respiratory distress syndrome.
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Immune, hormone, and muscle energy links to recovery after ARDS
This project looks at why some ARDS survivors have ongoing weakness and how immune, hormone, and muscle energy factors might influence recovery.</n>
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Understanding why some people with severe lung injury get worse and how to tailor therapy
A patient-focused program that looks at why people develop sepsis-associated ARDS and how their bodies respond, with the goal of guiding better, personalized treatments.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.