Investigating the roles of LynA and LynB kinases in immune signaling related to lupus
Functions of LynA and LynB kinases in dendritic-cell pro-inflammatory signaling and lupus
This study is looking at two types of a protein called Lyn to see how they affect the immune system and their role in lupus, with the hope that what we learn could help create better treatments for people with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11141294 on NIH RePORTER |
What this research studies
This research explores how two forms of the Lyn kinase, LynA and LynB, affect immune responses and their connection to systemic lupus erythematosus (SLE). By studying genetically modified mice, the researchers aim to understand the distinct functions of these kinases in regulating inflammation and autoimmunity. The study will also investigate how changes in the expression of these kinases can influence immune signaling pathways, potentially leading to new therapeutic strategies for lupus. Patients may benefit from insights gained about the immune system's regulation and the development of targeted treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic lupus erythematosus or those with a family history of autoimmune diseases.
Not a fit: Patients with autoimmune conditions unrelated to lupus or those without any autoimmune diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that better manage or prevent lupus and other autoimmune diseases.
How similar studies have performed: Previous research has shown that targeting specific immune signaling pathways can lead to significant advancements in treating autoimmune diseases, suggesting this approach may also yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Freedman, Tanya S. — University of Minnesota
- Study coordinator: Freedman, Tanya S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.