Investigating the role of Tyk2 and cytokines in autoimmune salivary gland disease.
Official title: Tyk2 and Associated Cytokines in Salivary Gland Autoimmunity
Funded at University of Iowa · NIH-11061060 · Data updated 2026-11-12
This study is looking at Sjögren’s disease, which causes dry mouth and dry eyes, to learn more about how it starts in the body, using mice that have a similar condition, so we can find better ways to diagnose and treat it for people like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | July 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $519,763 |
| NIH project number | 5R01DE032328-03 |
| Project ID | NIH-11061060 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Sjögren’s disease or those experiencing symptoms related to salivary gland dysfunction.
✕Less likely to help
Patients with autoimmune conditions unrelated to salivary gland function may not benefit from this research.
What this research studies
This research focuses on Sjögren’s disease, a chronic autoimmune condition that leads to the destruction of salivary and tear glands, causing severe dry mouth and dry eyes. The study aims to understand the early immunological mechanisms involved in this disease by using a mouse model that mimics human Sjögren’s. Researchers will explore how the Tyk2 gene and associated cytokines contribute to the development of this autoimmune response, with the goal of identifying potential targets for earlier diagnosis and more effective treatments.
Why it matters
Potential benefit: If successful, this research could lead to earlier diagnosis and new therapies for patients suffering from Sjögren’s disease.
How similar studies have gone: Previous research has shown promise in understanding autoimmune mechanisms through similar approaches, but this specific investigation into Tyk2 and Sjögren’s disease is relatively novel.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Lieberman, Scott Matthew — University of Iowa
- Study coordinator: Lieberman, Scott Matthew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.