Investigating the role of TREK-1 potassium channels in Acute Respiratory Distress Syndrome (ARDS)
Official title: The Role of TREK-1 potassium channels in ARDS
Funded at University of California Los Angeles · NIH-10945565 · Data updated 2026-11-12
This study is looking at how a specific type of potassium channel in the lungs might influence inflammation during Acute Respiratory Distress Syndrome (ARDS), with the goal of finding new ways to help patients breathe better when they are facing this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 16, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $782,362 |
| NIH project number | 1R01HL175464-01 |
| Project ID | NIH-10945565 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with Acute Respiratory Distress Syndrome, particularly those experiencing severe respiratory distress due to infections like COVID-19.
✕Less likely to help
Patients with mild respiratory issues or those not diagnosed with ARDS may not benefit from this research.
What this research studies
This research focuses on understanding how TREK-1 potassium channels affect inflammation in the lungs during Acute Respiratory Distress Syndrome (ARDS). Researchers will explore the role of these channels in a more complex model of ARDS that simulates real-life conditions, including infections and mechanical ventilation. By identifying how these channels function, the study aims to develop new therapeutic strategies that could improve patient outcomes. The research will involve laboratory experiments that replicate the inflammatory environment in the lungs.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce mortality rates and improve recovery for patients with ARDS.
How similar studies have gone: While there has been significant research on ARDS, the specific focus on TREK-1 potassium channels in this context is relatively novel and has not been extensively tested.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Schwingshackl, Andreas — University of California Los Angeles
- Study coordinator: Schwingshackl, Andreas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.