Investigating the role of specific RNA molecules in respiratory syncytial virus infections
Official title: PIWIL4 and piRNAs in RSV Infection
Funded at University of Texas Med Br Galveston · NIH-10767367 · Data updated 2026-11-12
This study is looking at how the respiratory syncytial virus (RSV) impacts people, especially older adults and those with weakened immune systems, by exploring tiny RNA molecules that might help us understand and treat lung problems caused by the virus.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Med Br Galveston NIH-funded |
| Lab location | 1 site (Galveston, United States) |
| Project start | January 25, 2023 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $200,000 |
| NIH project number | 5R21AI171664-02 |
| Project ID | NIH-10767367 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include elderly individuals and those with weakened immune systems who are at higher risk for severe RSV infections.
✕Less likely to help
Patients who are not elderly or immunocompromised may not benefit directly from this research.
What this research studies
This research focuses on understanding how respiratory syncytial virus (RSV) affects the body, particularly in vulnerable populations like the elderly and immunocompromised individuals. It explores the role of small non-coding RNAs, specifically piwi RNAs, in the body's response to RSV infection. By examining how these RNA molecules change during infection, the research aims to uncover new insights into the mechanisms of RSV-induced lung disease and potentially identify new therapeutic targets. The study employs advanced molecular biology techniques to analyze RNA expression profiles in infected cells.
Why it matters
Potential benefit: If successful, this research could lead to the development of effective treatments or vaccines for RSV, significantly improving outcomes for affected patients.
How similar studies have gone: While the role of piRNAs in viral infections is a relatively novel area of research, previous studies have shown promise in understanding other viral diseases through similar approaches.
Where this research is happening
-
University of Texas Med Br Galveston
Galveston, United States Active
Researchers
- Principal investigator: Casola, Antonella — University of Texas Med Br Galveston
- Study coordinator: Casola, Antonella
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.