Investigating the role of specific immune cells in rheumatoid arthritis
Architecture and interactions of Granzyme K+ CD8 T cells in inflamed synovium in rheumatoid arthritis
This study is looking at how certain immune cells called CD8 T cells interact with other cells in the inflamed joints of people with rheumatoid arthritis, focusing on a special protein they produce that might affect inflammation and tissue damage, with the hope of finding new ways to help manage the condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10993153 on NIH RePORTER |
What this research studies
This research focuses on understanding how CD8 T cells interact with fibroblasts in the inflamed synovial tissue of patients with rheumatoid arthritis (RA). The study aims to explore the unique characteristics of these T cells, particularly their high expression of granzyme K, which may influence inflammation and tissue damage. By using advanced imaging techniques and mouse models, the research will assess how granzyme K affects fibroblast behavior and contributes to the inflammatory environment in RA. Patients may benefit from insights that could lead to new therapeutic strategies targeting these immune interactions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rheumatoid arthritis who are experiencing active inflammation.
Not a fit: Patients with rheumatoid arthritis who are in remission or those with other autoimmune diseases unrelated to the mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to novel treatments that better manage inflammation and tissue damage in rheumatoid arthritis.
How similar studies have performed: While the specific focus on granzyme K in this context is novel, similar studies have shown promise in understanding immune cell interactions in autoimmune diseases.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Jonsson, Anna Helena — University of Colorado Denver
- Study coordinator: Jonsson, Anna Helena
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.