Investigating the role of specific immune cells in abdominal aortic aneurysm
Role of ILC2 and eosinophils in abdominal aortic aneurysm
This study is looking at how certain immune cells in the body might play a role in the growth of abdominal aortic aneurysms (AAA), with the hope of finding new ways to treat this condition without surgery, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10756121 on NIH RePORTER |
What this research studies
This research focuses on understanding how group 2 innate lymphoid cells (ILC2) and eosinophils contribute to the development of abdominal aortic aneurysm (AAA). Researchers will explore the relationship between these immune cells and cardiovascular diseases, particularly how their presence or absence affects AAA growth. By studying animal models and their immune responses, the research aims to uncover potential new therapeutic targets for non-invasive treatments. Patients may benefit from insights that could lead to innovative approaches for managing AAA.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for or diagnosed with abdominal aortic aneurysm.
Not a fit: Patients with other unrelated cardiovascular conditions may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new non-invasive treatment options for patients with abdominal aortic aneurysm.
How similar studies have performed: While the role of ILC2 and eosinophils in AAA is not extensively studied, similar research in other cardiovascular conditions has shown promising results.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Libby, Peter — Brigham and Women's Hospital
- Study coordinator: Libby, Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.