Investigating the role of specific immune cells in abdominal aortic aneurysm
Official title: Role of ILC2 and eosinophils in abdominal aortic aneurysm
Funded at Brigham and Women's Hospital · NIH-10756121 · Data updated 2026-11-12
This study is looking at how certain immune cells in the body might play a role in the growth of abdominal aortic aneurysms (AAA), with the hope of finding new ways to treat this condition without surgery, which could help patients in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $666,455 |
| NIH project number | 5R01HL151627-04 |
| Project ID | NIH-10756121 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for or diagnosed with abdominal aortic aneurysm.
✕Less likely to help
Patients with other unrelated cardiovascular conditions may not receive direct benefits from this research.
What this research studies
This research focuses on understanding how group 2 innate lymphoid cells (ILC2) and eosinophils contribute to the development of abdominal aortic aneurysm (AAA). Researchers will explore the relationship between these immune cells and cardiovascular diseases, particularly how their presence or absence affects AAA growth. By studying animal models and their immune responses, the research aims to uncover potential new therapeutic targets for non-invasive treatments. Patients may benefit from insights that could lead to innovative approaches for managing AAA.
Why it matters
Potential benefit: If successful, this research could lead to new non-invasive treatment options for patients with abdominal aortic aneurysm.
How similar studies have gone: While the role of ILC2 and eosinophils in AAA is not extensively studied, similar research in other cardiovascular conditions has shown promising results.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Libby, Peter — Brigham and Women's Hospital
- Study coordinator: Libby, Peter
Related research
Other NIH-funded projects on the same topics.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
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Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.