Investigating the role of NLRP10 inflammasome in sepsis caused by Gram-positive bacteria
Official title: NLRP10 Inflamasome in Gram-positive Sepsis
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-10929339 · Data updated 2026-11-12
This study is looking at how a part of the immune system called the NLRP10 inflammasome affects sepsis caused by certain bacteria, like those that lead to pneumonia, to find better ways to help patients recover from this serious condition.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $43,416 |
| NIH project number | 5F31HL168986-02 |
| Project ID | NIH-10929339 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of all ages who are experiencing sepsis due to Gram-positive bacterial infections, particularly those with pneumonia.
✕Less likely to help
Patients with sepsis caused by Gram-negative bacteria or other non-bacterial infections may not benefit from this research.
What this research studies
This research focuses on understanding how the NLRP10 inflammasome contributes to sepsis, particularly in cases triggered by Gram-positive bacteria like those causing pneumonia. The study aims to explore the immune response, specifically the recruitment and activation of neutrophils, which are crucial for fighting infections. By examining the mechanisms of inflammation and tissue damage, the research seeks to identify new treatment strategies that could improve patient outcomes in sepsis. This involves laboratory experiments and analysis of immune responses in relevant models.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches for treating sepsis, potentially reducing mortality and improving recovery rates.
How similar studies have gone: While the role of NLRP3 inflammasome has been well-studied, the specific investigation of NLRP10 in Gram-positive pneumonia is relatively novel and has not been extensively tested.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Le, John — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Le, John
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.