Investigating the role of netrin-1 in protecting blood vessels
Netrin-1 and Netrin-1 Preconditioned EPCs in Vascular Protection
This study is looking at how a special protein called netrin-1 can help protect blood vessels from damage caused by heart-related issues like atherosclerosis, with the hope of finding new ways to treat these conditions and improve heart health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10557815 on NIH RePORTER |
What this research studies
This research focuses on understanding how netrin-1 and netrin-1 pre-conditioned endothelial progenitor cells (EPCs) can protect blood vessels from damage caused by conditions like atherosclerosis. The study explores the molecular mechanisms by which netrin-1 enhances the survival of EPCs and inhibits harmful processes in blood vessels. By examining these pathways, the research aims to develop new therapeutic strategies to prevent vascular diseases. Patients may benefit from insights that could lead to innovative treatments for cardiovascular conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with non-vascular related health issues or those not at risk for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce the risk of atherosclerosis and improve vascular health.
How similar studies have performed: Other research has shown promising results in using similar approaches to enhance vascular protection, suggesting potential for success in this area.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Cai, Hua Linda — University of California Los Angeles
- Study coordinator: Cai, Hua Linda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.