Investigating the role of MARK1 in brain development and cognitive function
Official title: MARK1 in dendritic spine neoteny
Funded at Rutgers Biomedical and Health Sciences · NIH-10753728 · Data updated 2026-11-12
This study is looking at how a gene called MARK1 affects tiny structures in the brain that help with learning and memory, and it's for anyone interested in understanding how our genes might play a role in conditions like autism and bipolar disorder.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | June 15, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $401,239 |
| NIH project number | 1R21NS134233-01 |
| Project ID | NIH-10753728 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults diagnosed with bipolar disorder or autism spectrum disorders.
✕Less likely to help
Patients with cognitive impairments not related to the studied genetic factors may not benefit from this research.
What this research studies
This research explores how a specific gene, MARK1, influences the development of dendritic spines in the human brain, which are crucial for learning and memory. By examining the molecular mechanisms behind the unique maturation of these spines in humans compared to other species, the study aims to uncover insights into cognitive performance and neurodevelopmental disorders. The research involves analyzing genetic variations linked to conditions like autism and bipolar disorder to understand their impact on brain function.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological basis of cognitive abilities and neurodevelopmental disorders, potentially informing treatment strategies.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of neurodevelopmental disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Zhang, Huaye — Rutgers Biomedical and Health Sciences
- Study coordinator: Zhang, Huaye
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.