Investigating the role of JAK-STAT in Celiac Disease
A generic and immunological investigation of JAK-STAT in the pathogenesis of Celiac
This study is looking at how certain genes and immune responses related to the JAK-STAT pathway might play a role in Celiac Disease, especially in families affected by it and in individuals with Down Syndrome, to find new ways to help manage the condition better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11082228 on NIH RePORTER |
What this research studies
This research focuses on understanding how the JAK-STAT signaling pathway contributes to the development of Celiac Disease (CeD), an autoimmune condition triggered by gluten in genetically susceptible individuals. The study will involve genetic investigations of patients with familial CeD to identify specific genetic variants that may influence the JAK-STAT pathway. Additionally, the research will explore the immune response in patients with conditions like Down Syndrome, who have a higher risk of CeD due to altered JAK-STAT activation. By examining these mechanisms, the research aims to uncover potential therapeutic targets for better management of CeD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a genetic predisposition to Celiac Disease, particularly those with familial cases or associated genetic conditions like Down Syndrome.
Not a fit: Patients without a genetic predisposition to Celiac Disease or those who do not have autoimmune conditions related to the JAK-STAT pathway may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies for Celiac Disease beyond the current gluten-free diet.
How similar studies have performed: Previous research has shown promising results in understanding the JAK-STAT pathway in other autoimmune diseases, suggesting potential for success in this novel investigation of Celiac Disease.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kong, Xiao-Fei — Ut Southwestern Medical Center
- Study coordinator: Kong, Xiao-Fei
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.