Investigating the role of immune receptors in skin inflammation related to lupus
The role of TLRs, Type II IFN and Type III IFN in a Murine Model of Autoinflammation
This study is looking at how certain immune cells cause skin inflammation in people with lupus, using a mouse model to help find better treatments for the skin issues that come with the disease.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-11010861 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific immune receptors contribute to skin inflammation in lupus, a complex autoimmune disease. By using a mouse model that mimics lupus-like skin conditions, researchers aim to identify the mechanisms that lead to skin lesions and other symptoms associated with the disease. The study will explore the roles of various immune cells and signaling pathways involved in the inflammation process, which could provide insights into better treatment options for patients. The approach includes transferring T cells to induce skin inflammation and analyzing the resulting immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lupus or those experiencing autoimmune skin conditions.
Not a fit: Patients with non-autoimmune skin conditions or those not diagnosed with lupus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients suffering from lupus and related skin conditions.
How similar studies have performed: Previous research has shown success in using similar murine models to study autoimmune diseases, indicating potential for meaningful findings in this area.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Marshak-Rothstein, Ann — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Marshak-Rothstein, Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.