Investigating the role of hydrogen sulfide in diabetes and heart disease
Circulating hydrogen sulfide, diabetes and diabetes-related cardiovascular disease
This study is looking at how a gas called hydrogen sulfide might affect the way type 2 diabetes develops and how it can lead to heart problems, with the hope of finding new ways to help manage diabetes and keep your heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10911195 on NIH RePORTER |
What this research studies
This research explores how hydrogen sulfide (H2S) may influence the development of type 2 diabetes and its associated cardiovascular complications. By examining the relationship between H2S levels and diabetes-related heart disease, the study aims to identify new mechanisms that could be targeted for treatment. The approach includes case-cohort and longitudinal studies to gather data on H2S and its effects on insulin secretion and glucose metabolism. This research could lead to new therapeutic strategies for managing diabetes and preventing cardiovascular issues.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type 2 diabetes, particularly those experiencing cardiovascular complications.
Not a fit: Patients without diabetes or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve diabetes management and reduce the risk of heart disease in patients.
How similar studies have performed: While preclinical studies have shown promising results regarding H2S and diabetes, this research aims to fill the gap with prospective studies in humans, making it a novel approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Totah, Rheem Angela — University of Washington
- Study coordinator: Totah, Rheem Angela
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.