Investigating the role of HEG1 in blood vessel health and heart disease
HEG1 in endothelial function and atherosclerosis
This study is looking at how a gene called HEG1 affects blood vessel health and may play a role in atherosclerosis, which can lead to heart problems, and it's for anyone interested in understanding how blood flow and inflammation impact their cardiovascular health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10854836 on NIH RePORTER |
What this research studies
This research focuses on understanding how the HEG1 gene affects blood vessel function and contributes to atherosclerosis, a condition that can lead to heart attacks and strokes. The study examines how changes in blood flow influence the expression of HEG1 and its role in inflammation and vascular integrity. By using advanced techniques like single-cell RNA sequencing and experiments on human aortic endothelial cells, the researchers aim to uncover the mechanisms by which HEG1 impacts cardiovascular health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for atherosclerosis or those with existing cardiovascular conditions.
Not a fit: Patients with non-cardiovascular related health issues or those not at risk for atherosclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating atherosclerosis and related cardiovascular diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of similar genes in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Jo, Hanjoong — Emory University
- Study coordinator: Jo, Hanjoong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.