Investigating the role of G6PC2 in regulating blood sugar levels
Official title: G6PC Enzymology, Structure, Function and Role in the Regulation of Fasting Blood Glucose
Funded at Vanderbilt University · NIH-11014344 · Data updated 2026-11-12
This study is looking at a special enzyme called G6PC2 to see how it helps control blood sugar levels, which could help us find new ways to keep people healthy and lower their risk of type 2 diabetes and heart problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | February 1, 2023 |
| Project end | January 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $419,765 |
| NIH project number | 5R01DK132259-03 |
| Project ID | NIH-11014344 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with elevated fasting blood glucose levels, particularly those who are pre-diabetic or at risk of developing type 2 diabetes.
✕Less likely to help
Patients with well-controlled diabetes or those who do not have any issues with blood glucose regulation may not benefit from this research.
What this research studies
This research focuses on the enzyme G6PC2, which plays a crucial role in converting glucose-6-phosphate into glucose. By studying how G6PC2 functions in pancreatic beta cells, the research aims to understand its impact on fasting blood glucose levels and the risk of developing type 2 diabetes and cardiovascular diseases. The approach includes genetic and biochemical analyses to identify variations in the G6PC2 gene that may affect its activity. If successful, this research could lead to new treatments that lower blood sugar levels and improve health outcomes for individuals at risk of diabetes.
Why it matters
Potential benefit: If successful, this research could provide new therapeutic options for managing blood sugar levels in patients at risk of diabetes and cardiovascular diseases.
How similar studies have gone: Previous research has shown promising results in targeting similar metabolic pathways for diabetes management, indicating that this approach may be viable.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: O'brien, Richard M — Vanderbilt University
- Study coordinator: O'brien, Richard M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.