Investigating the role of Foxp transcription factors in immune regulation
Official title: Foxp transcription factors in regulatory T cells
Funded at Veterans Admin Palo Alto Health Care Sys · NIH-11252513 · Data updated 2026-11-12
This study is looking at how certain proteins, called Foxp1 and Foxp4, affect the growth and job of special immune cells that help keep our immune system in check, and it’s for anyone interested in understanding how these changes might impact autoimmune diseases and organ transplants.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Admin Palo Alto Health Care Sys NIH-funded |
| Lab location | 1 site (Palo Alto, United States) |
| Project start | January 1, 2021 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| NIH project number | 5I01BX005142-05 |
| Project ID | NIH-11252513 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research would include individuals with autoimmune diseases or those undergoing transplantation who may benefit from improved immune regulation.
✕Less likely to help
Patients with non-autoimmune conditions or those not requiring immune modulation may not receive any benefit from this research.
What this research studies
This research focuses on understanding how specific transcription factors, known as Foxp1 and Foxp4, influence the development and function of regulatory T cells (Tregs), which are essential for maintaining immune tolerance. By creating genetically modified mice that lack these factors, researchers aim to observe changes in Treg development and their ability to suppress immune responses. The study employs advanced techniques such as high throughput sequencing to analyze gene regulation and will test the effects of these changes in models of autoimmune diseases and transplantation.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating autoimmune diseases and improving transplant outcomes by enhancing the function of regulatory T cells.
How similar studies have gone: Previous research has shown promising results in understanding the role of transcription factors in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Veterans Admin Palo Alto Health Care Sys
Palo Alto, United States Active
Researchers
- Principal investigator: Maltzman, Jonathan S — Veterans Admin Palo Alto Health Care Sys
- Study coordinator: Maltzman, Jonathan S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.