Investigating the role of CCR6 in pancreatic cancer and its immune response
Official title: The role of CCR6 in Pancreatic Cancer and Tregs
Funded at Medical College of Wisconsin · NIH-11110288 · Data updated 2026-11-12
This study is looking at a special type of immune cell that may help pancreatic cancer grow, and it aims to find ways to target these cells so that the body can better fight the cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | April 15, 2024 |
| Project end | April 14, 2028 |
| Funding year | 2025 |
| Award (this year) | $51,628 |
| NIH project number | 5F30CA291095-02 |
| Project ID | NIH-11110288 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with pancreatic cancer who may benefit from improved immune therapies.
✕Less likely to help
Patients with other types of cancer or those who do not have pancreatic cancer may not receive any benefit from this research.
What this research studies
This research focuses on understanding how a specific type of immune cell, known as regulatory T cells (Tregs), influences the progression of pancreatic cancer. The study aims to identify a subset of Tregs that express the CCR6 protein and have enhanced abilities to suppress the immune response against tumors. By using laboratory assays and animal models, the researchers will explore how the chemokine CCL20 affects these Tregs and their role in creating an immunosuppressive environment around pancreatic tumors. The ultimate goal is to find a way to selectively target these Tregs to improve the body's anti-tumor immune response.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that enhance the immune system's ability to fight pancreatic cancer.
How similar studies have gone: Previous research has shown promise in targeting immune cells in cancer, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Drouillard, Donovan G — Medical College of Wisconsin
- Study coordinator: Drouillard, Donovan G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.