Investigating the role of BAF60c in abdominal aortic aneurysms
BAF60c and abdominal aortic aneurysm
This study is looking into how certain proteins affect the health of blood vessel cells and may lead to abdominal aortic aneurysms, with the goal of finding new ways to treat this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10846748 on NIH RePORTER |
What this research studies
This research focuses on understanding the mechanisms behind abdominal aortic aneurysms (AAA), a serious condition that can lead to life-threatening ruptures. The study aims to explore how chromatin remodeling, particularly involving the BAF60 family of proteins, affects the health of vascular smooth muscle cells and contributes to AAA development. By examining tissue samples from humans and mice, researchers hope to identify new therapeutic targets that could lead to effective drug treatments for AAA. The approach combines molecular biology techniques with insights into cardiovascular health to uncover potential interventions.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals at risk for abdominal aortic aneurysms, particularly those with a family history or other cardiovascular risk factors.
Not a fit: Patients who do not have abdominal aortic aneurysms or are not at risk for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new drug therapies that effectively prevent or treat abdominal aortic aneurysms, significantly reducing mortality rates.
How similar studies have performed: While the role of chromatin remodeling in cardiovascular diseases is being explored, the specific focus on BAF60c in AAA is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Zhang, Jifeng — University of Michigan at Ann Arbor
- Study coordinator: Zhang, Jifeng
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.