Investigating the role of BAF60c in abdominal aortic aneurysms
Official title: BAF60c and abdominal aortic aneurysm
Funded at University of Michigan at Ann Arbor · NIH-10846748 · Data updated 2026-11-12
This study is looking into how certain proteins affect the health of blood vessel cells and may lead to abdominal aortic aneurysms, with the goal of finding new ways to treat this serious condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 1, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $532,877 |
| NIH project number | 5R01HL153710-04 |
| Project ID | NIH-10846748 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals at risk for abdominal aortic aneurysms, particularly those with a family history or other cardiovascular risk factors.
✕Less likely to help
Patients who do not have abdominal aortic aneurysms or are not at risk for developing them may not benefit from this research.
What this research studies
This research focuses on understanding the mechanisms behind abdominal aortic aneurysms (AAA), a serious condition that can lead to life-threatening ruptures. The study aims to explore how chromatin remodeling, particularly involving the BAF60 family of proteins, affects the health of vascular smooth muscle cells and contributes to AAA development. By examining tissue samples from humans and mice, researchers hope to identify new therapeutic targets that could lead to effective drug treatments for AAA. The approach combines molecular biology techniques with insights into cardiovascular health to uncover potential interventions.
Why it matters
Potential benefit: If successful, this research could lead to new drug therapies that effectively prevent or treat abdominal aortic aneurysms, significantly reducing mortality rates.
How similar studies have gone: While the role of chromatin remodeling in cardiovascular diseases is being explored, the specific focus on BAF60c in AAA is relatively novel and has not been extensively tested in prior studies.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Zhang, Jifeng — University of Michigan at Ann Arbor
- Study coordinator: Zhang, Jifeng
Related research
Other NIH-funded projects on the same topics.
-
How the small regulator miR-146a affects abdominal aortic aneurysm
This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.
-
MOF’s role in weakening the aorta and stopping aneurysm growth
Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.
-
Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm
A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.
-
Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth
A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.
-
Using genetics to uncover how abdominal aortic aneurysms develop
A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.
-
Phospholipid-based nanotherapies to treat abdominal aortic aneurysm
A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.