Investigating the role of bacterial polyphosphates in sepsis
Bacterial polyphosphates in sepsis
This study is looking at how certain substances made by bacteria might affect the body's ability to fight off sepsis, a serious infection, and aims to find new ways to help patients recover better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10773098 on NIH RePORTER |
What this research studies
This research focuses on understanding how bacterial polyphosphates contribute to sepsis, a severe infection that can lead to organ failure. The study aims to explore the interactions between these bacterial metabolites and the body's immune response, particularly how they may hinder the body's ability to fight infections. By examining the effects of different chain lengths of polyphosphates, the research seeks to identify potential therapeutic targets that could improve patient outcomes in sepsis. The approach includes laboratory experiments using animal models and cell cultures to assess the impact of polyphosphates on immune cell behavior and inflammation.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with sepsis or severe bacterial infections.
Not a fit: Patients with non-infectious conditions or those not experiencing sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for sepsis, potentially improving survival rates and recovery for affected patients.
How similar studies have performed: While the role of polyphosphates in sepsis is an emerging field, preliminary studies have shown promising results in related areas, indicating potential for success.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Bosmann, Markus — Boston University Medical Campus
- Study coordinator: Bosmann, Markus
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.