Investigating the role of a specific protein in depression and its effects on treatment for men and women
Sex-specific role of CCL5/CCR5 axis in depression and its therapeutic implication
This study is looking at how certain biological factors might affect depression differently in men and women, especially by exploring how stress and inflammation impact female mice, with the hope of finding better treatments for people with depression based on their unique experiences.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project ID | NIH-10910994 on NIH RePORTER |
What this research studies
This research focuses on understanding how the CCL5/CCR5 axis contributes to depression, particularly examining differences between men and women. By using a novel model of chronic social defeat stress, the study aims to identify how inflammation affects depression-like behaviors in female mice, which has been less studied compared to males. The findings could lead to better-targeted therapies for depression based on sex-specific responses to treatment. Patients may be involved in discussions about their experiences with depression and treatment responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing major depressive disorder, particularly those who are veterans or have a history of stress-related conditions.
Not a fit: Patients who do not have major depressive disorder or those who are not affected by stress-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for depression that consider the differences between men and women.
How similar studies have performed: While the specific approach of examining the CCL5/CCR5 axis in female depression is relatively novel, previous studies have shown success in understanding sex differences in depression and the role of inflammation.
Where this research is happening
Bronx, United States
- James J Peters VA Medical Center — Bronx, United States (Active)
Researchers
- Principal investigator: Wang, Jun — James J Peters VA Medical Center
- Study coordinator: Wang, Jun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.