Investigating the role of a specific enzyme in systemic sclerosis
Role of PTP4A1 in systemic sclerosis
This study is looking at how a specific protein might play a role in worsening systemic sclerosis, a condition that causes hardening of the skin and organs, to help find new ways to treat it and improve patients' lives.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10668208 on NIH RePORTER |
What this research studies
This research focuses on systemic sclerosis, an autoimmune disease that leads to excessive fibrosis in the skin and internal organs. The study aims to understand how a protein tyrosine phosphatase called PTP4A1 contributes to the disease by enhancing signaling pathways that promote fibrosis. By examining the molecular interactions of PTP4A1 with other proteins, the research seeks to uncover potential therapeutic targets for preventing disease progression. Patients may benefit from insights that could lead to new treatments for this challenging condition.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with systemic sclerosis who are experiencing progressive fibrosis.
Not a fit: Patients with other autoimmune diseases or those not diagnosed with systemic sclerosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to halt or reverse fibrosis in patients with systemic sclerosis.
How similar studies have performed: While the role of PTP4A1 in systemic sclerosis has not been extensively studied, similar approaches targeting signaling pathways in other fibrotic diseases have shown promise.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Bottini, Nunzio — Cedars-Sinai Medical Center
- Study coordinator: Bottini, Nunzio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.