Investigating the role of a protein in preventing precancerous changes in the colon
Official title: Deleted in malignant brain tumors 1 (DMBT1) expression and impact on colonic dysplasia
Funded at Vanderbilt University · NIH-10998038 · Data updated 2026-11-12
This study is looking at a protein called DMBT1 to see how it might help prevent precancerous growths in the colon, using mice to learn more about how it works and could protect against colorectal cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University NIH-funded |
| Lab location | 1 site (Nashville, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $34,370 |
| NIH project number | 1F31CA294983-01 |
| Project ID | NIH-10998038 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of colonic dysplasia or those at high risk for developing colorectal cancer.
✕Less likely to help
Patients without any precancerous lesions or those with advanced colorectal cancer may not benefit from this research.
What this research studies
This research focuses on understanding how the protein Deleted in Malignant Brain Tumors 1 (DMBT1) affects the development of precancerous lesions in the colon. By examining the expression of DMBT1 in various mouse models and comparing it to normal colon cells, the study aims to uncover its potential role in regulating cell growth and differentiation. The researchers will utilize advanced techniques like immunofluorescence and spatial transcriptomics to analyze DMBT1's behavior in the colon, which could provide insights into its protective functions against colorectal cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing colorectal cancer by enhancing the body's natural defenses against precancerous changes.
How similar studies have gone: Other research has shown promising results in understanding the role of host proteins in cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Vanderbilt University
Nashville, United States Active
Researchers
- Principal investigator: Green, Emily H — Vanderbilt University
- Study coordinator: Green, Emily H
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.