Investigating the long-term effects of the anti-obesity medication Phentermine
1/2, Clinical Coordinating Center for the Long-term Effectiveness of the Anti-obesity medication Phentermine: the LEAP Trial
This study is looking at how well Phentermine, a weight loss medication, works over a long time when combined with healthy lifestyle changes, and it's for people dealing with obesity and related health concerns.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10908539 on NIH RePORTER |
What this research studies
This research aims to evaluate the long-term effectiveness and safety of Phentermine, a commonly prescribed anti-obesity medication, when paired with lifestyle interventions for weight management. It will involve participants from five centers across the United States, focusing on how this medication can help individuals who struggle with obesity and related health issues. The study will assess weight loss outcomes, cardiovascular risk factors, and any potential adverse effects associated with long-term use of Phentermine.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with obesity who may benefit from pharmacotherapy in conjunction with lifestyle changes.
Not a fit: Patients who are not struggling with obesity or those who have contraindications to Phentermine may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide evidence for the safe long-term use of Phentermine, potentially improving weight management strategies for patients with obesity.
How similar studies have performed: While there have been studies on obesity treatments, this research is novel as it specifically focuses on the long-term effects of Phentermine, which has not been extensively studied in a controlled trial setting.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Lewis, Kristina H — Wake Forest University Health Sciences
- Study coordinator: Lewis, Kristina H
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.