Investigating the long-term effects of the anti-obesity medication Phentermine.
2/2, Data Coordinating Center for the Long-term Effectiveness of the Anti-obesity medication Phentermine: the LEAP Trial
This study is looking at how well Phentermine, a weight loss medication, works over time when paired with healthy lifestyle changes, and it's for people who want to manage their weight and improve their health.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University Health Sciences NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10908410 on NIH RePORTER |
What this research studies
This research focuses on understanding the long-term effectiveness of Phentermine, an anti-obesity medication, when combined with lifestyle interventions for weight loss. It aims to evaluate how this medication impacts weight management and related health factors, such as blood pressure and cardiovascular risk, over an extended period. The study will involve participants from five centers across the United States, who will be monitored for their weight loss progress and any potential adverse effects of the medication. By gathering comprehensive data, the research seeks to provide insights into the safety and efficacy of long-term Phentermine use.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who are struggling with obesity and may benefit from medication-assisted weight loss.
Not a fit: Patients who are not overweight or obese, or those who have contraindications to Phentermine, may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide evidence for the safe long-term use of Phentermine, potentially improving weight management strategies for patients with obesity.
How similar studies have performed: While there have been studies on obesity treatments, this research is novel as it specifically investigates the long-term effects of Phentermine, which has not been thoroughly evaluated in high-quality trials.
Where this research is happening
Winston-Salem, United States
- Wake Forest University Health Sciences — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Pajewski, Nicholas M. — Wake Forest University Health Sciences
- Study coordinator: Pajewski, Nicholas M.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.