Investigating the link between HIV, blood cell mutations, and heart disease
Official title: Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
Funded at University of California Los Angeles · NIH-11042980 · Data updated 2026-11-12
This study is looking at how living with HIV for a long time and getting older might increase the chances of heart problems, and it will check how certain blood cell changes could help us find new treatments to keep your heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | July 5, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $159,485 |
| NIH project number | 3R01HL170600-02S1 |
| Project ID | NIH-11042980 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living with HIV who are aging and may be at risk for cardiovascular disease.
✕Less likely to help
Patients who are not living with HIV or who do not have cardiovascular disease may not benefit from this research.
What this research studies
This research explores how chronic HIV infection and the aging population living with HIV may lead to an increased risk of cardiovascular disease (CVD). It focuses on understanding the role of clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) in this risk. By examining the relationship between these blood cell mutations and CVD, the study aims to identify potential immunomodulatory therapies that could improve heart health in people living with HIV. Patients may be involved in assessments that analyze their blood and cardiovascular health over the course of the study.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease in individuals living with HIV.
How similar studies have gone: Previous research has shown that similar approaches to studying blood cell mutations and cardiovascular risk have been successful in other populations, indicating potential for success in this context as well.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Hsue, Priscilla Y. — University of California Los Angeles
- Study coordinator: Hsue, Priscilla Y.
Related research
Other NIH-funded projects on the same topics.
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Understanding how genetic changes in blood cells relate to heart disease in people with HIV
A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.
-
Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients
This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.
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Understanding how age-related blood changes affect heart disease risk in people with HIV
This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.
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Blood cell mutations, chromosome changes, and heart disease in people living with HIV
This project looks at whether age-related blood cell mutations and large chromosome changes help explain why people living with HIV have a higher risk of heart disease.
-
Clonal blood mutations and chromosome changes linked to heart disease in people with HIV
Researchers will look for whether age-related blood mutations and large chromosome changes raise heart disease risk in people living with HIV.
-
How Lp(a) levels affect heart and artery disease risk in people with HIV
This project looks at whether higher levels of a blood lipid called Lp(a) raise the chance of heart and artery disease for people living with HIV.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.