Investigating the link between HIV, blood cell mutations, and heart disease
Evaluation of Novel Clonal Hematopoiesis Of InDEterminate Potential, Mosaic Chromosomal Alterations and CardioVascular Disease in HIV Infection (ENCODE CVD in HIV)
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA LOS ANGELES · NIH-11042980
This study is looking at how living with HIV for a long time and getting older might increase the chances of heart problems, and it will check how certain blood cell changes could help us find new treatments to keep your heart healthy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA LOS ANGELES (nih funded) |
| Locations | 1 site (LOS ANGELES, UNITED STATES) |
| Trial ID | NIH-11042980 on ClinicalTrials.gov |
What this research studies
This research explores how chronic HIV infection and the aging population living with HIV may lead to an increased risk of cardiovascular disease (CVD). It focuses on understanding the role of clonal hematopoiesis of indeterminate potential (CHIP) and mosaic chromosomal alterations (mCAs) in this risk. By examining the relationship between these blood cell mutations and CVD, the study aims to identify potential immunomodulatory therapies that could improve heart health in people living with HIV. Patients may be involved in assessments that analyze their blood and cardiovascular health over the course of the study.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are aging and may be at risk for cardiovascular disease.
Not a fit: Patients who are not living with HIV or who do not have cardiovascular disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that reduce the risk of heart disease in individuals living with HIV.
How similar studies have performed: Previous research has shown that similar approaches to studying blood cell mutations and cardiovascular risk have been successful in other populations, indicating potential for success in this context as well.
Where this research is happening
LOS ANGELES, UNITED STATES
- UNIVERSITY OF CALIFORNIA LOS ANGELES — LOS ANGELES, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HSUE, PRISCILLA Y. — UNIVERSITY OF CALIFORNIA LOS ANGELES
- Study coordinator: HSUE, PRISCILLA Y.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired Immune Deficiency Syndrome, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome, Acquired Immunodeficiency Syndrome Virus, Atherosclerotic Cardiovascular Disease