Investigating the impact of rare genetic variants linked to schizophrenia in the Amish population.
Multi-scale consequences of variants in the schizophrenia risk gene SETD1A in a population isolate.
This study is looking at how certain rare changes in a gene called SETD1A might increase the risk of schizophrenia, and it's specifically working with Amish individuals who have these changes to learn more about how they affect the brain and behavior.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11093990 on NIH RePORTER |
What this research studies
This research focuses on understanding how specific rare genetic variants in the SETD1A gene contribute to the risk of developing schizophrenia. By studying a unique population of Amish individuals who carry these variants, researchers aim to uncover the biological mechanisms behind this increased risk. The approach includes recruiting participants, collecting blood samples, and analyzing cognitive and behavioral traits associated with these genetic changes. This work seeks to bridge gaps in knowledge about the clinical implications of SETD1A variants in human neural cells.
Who could benefit from this research
Good fit: Ideal candidates for participation are Amish individuals who carry specific SETD1A genetic variants and their blood relatives.
Not a fit: Patients who do not belong to the Amish population or do not carry the SETD1A variants may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and potentially new treatments for schizophrenia.
How similar studies have performed: Previous research has shown success in studying genetic variants in isolated populations, suggesting this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Ament, Seth Abrams — University of Maryland Baltimore
- Study coordinator: Ament, Seth Abrams
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.