Investigating the immune response in Takotsubo Cardiomyopathy
Official title: Novel role of ROCK2 in Immune Mechanisms of Takotsubo Cardiomyopathy
Funded at Indiana University Indianapolis · NIH-11033681 · Data updated 2026-11-12
This study is looking at how the immune system affects Takotsubo Cardiomyopathy, a heart condition caused by extreme stress, to find new ways to help people who have had this condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | December 20, 2024 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $123,930 |
| NIH project number | 1K99HL177309-01 |
| Project ID | NIH-11033681 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced an episode of Takotsubo Cardiomyopathy and are at risk for further cardiovascular events.
✕Less likely to help
Patients with chronic heart conditions unrelated to stress-induced cardiomyopathy may not benefit from this research.
What this research studies
This research focuses on Takotsubo Cardiomyopathy (TCM), a serious heart condition triggered by extreme stress that leads to heart dysfunction. The study aims to understand the role of the immune system, particularly the involvement of macrophages and the enzyme ROCK2, in the development and progression of TCM. By examining how these immune mechanisms operate, the research seeks to identify potential treatment strategies for patients who have experienced TCM episodes. The approach includes both preclinical models and analysis of immune responses in human patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options and improved care for patients recovering from Takotsubo Cardiomyopathy.
How similar studies have gone: Previous studies have shown promising results in understanding immune mechanisms in heart conditions, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Fehrenbach, Daniel J — Indiana University Indianapolis
- Study coordinator: Fehrenbach, Daniel J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.