Investigating the immune response in a specific autoinflammatory disease
Radioresistant Innate Immunity in SAVI Tissue-Specific Autoinflammation
This study is looking at how the immune system works in babies with a serious condition called SAVI, using mice to help understand what causes lung problems, with the hope of finding better treatments for those affected.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10899703 on NIH RePORTER |
What this research studies
This research focuses on understanding the immune mechanisms involved in STING-Associated Vasculopathy with onset in Infancy (SAVI), a severe autoinflammatory disease. By utilizing a mouse model that mimics the human condition, researchers aim to explore how certain immune cells and molecular pathways contribute to lung inflammation and fibrosis. The study seeks to identify the underlying causes of these debilitating symptoms, which could lead to the development of more effective treatments for affected patients. The approach involves detailed analysis of immune responses and tissue changes in the context of this disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with STING-Associated Vasculopathy or related autoinflammatory conditions.
Not a fit: Patients with unrelated autoimmune diseases or those not exhibiting symptoms of SAVI may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve the quality of life for patients suffering from SAVI.
How similar studies have performed: Previous research has shown promise in understanding similar autoinflammatory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Marshak-Rothstein, Ann — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Marshak-Rothstein, Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.