Investigating the immune mechanisms behind autoimmune diabetes and nerve damage
Official title: Cellular and Genetic Mechanisms of Autoimmune Diabetes Associated Neuritis
Funded at Jackson Laboratory · NIH-10915475 · Data updated 2026-11-12
This study is looking at how type 1 diabetes might also harm nerves in the body, by checking out how certain immune cells interact with nerve proteins, which could help us understand why some people with diabetes experience nerve problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project start | September 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $410,158 |
| NIH project number | 5R01DK136472-02 |
| Project ID | NIH-10915475 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with type 1 diabetes who may also be experiencing symptoms of autoimmune neuropathies.
✕Less likely to help
Patients with type 1 diabetes who do not have any associated autoimmune neuropathies may not benefit from this research.
What this research studies
This research explores the connection between type 1 diabetes (T1D) and autoimmune neuropathies, focusing on how immune responses targeting pancreatic cells may also affect nerve cells. By studying specific lymphocyte populations in a new mouse model, researchers aim to understand the early immune responses that lead to nerve damage in patients with T1D. The study involves examining the interactions between B-lymphocytes and proteins expressed in the nervous system, which could reveal critical insights into the progression of nerve-related complications in diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating nerve damage in patients with type 1 diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the immune mechanisms of autoimmune diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Jackson Laboratory
Bar Harbor, United States Active
Researchers
- Principal investigator: Racine, Jeremy J — Jackson Laboratory
- Study coordinator: Racine, Jeremy J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.