Investigating the immune cells involved in type I diabetes
Official title: Spatiotemporal and molecular determinants of autoimmune T cell stemness and differentiation in type I diabetes
Funded at Weill Medical Coll of Cornell Univ · NIH-10995900 · Data updated 2026-11-12
This study is looking at how certain immune cells, called CD8 T cells, play a role in causing type 1 diabetes, using a mouse model to learn more about how these cells can harm insulin-producing cells in the pancreas, with the hope of finding new ways to prevent or treat the disease.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 26, 2024 |
| Project end | August 25, 2027 |
| Funding year | 2024 |
| Award (this year) | $48,974 |
| NIH project number | 1F31DK141119-01 |
| Project ID | NIH-10995900 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk of developing type I diabetes or those who have recently been diagnosed.
✕Less likely to help
Patients with type II diabetes or other non-autoimmune forms of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding how specific immune cells, particularly CD8 T cells, contribute to the development of type I diabetes (T1D). By using a mouse model that mimics human T1D, the researchers will explore the mechanisms that allow these immune cells to self-renew and differentiate, leading to the destruction of insulin-producing cells in the pancreas. The study employs advanced techniques such as imaging cytometry and spatial transcriptomics to gain insights into the cellular processes involved in this autoimmune disease. Ultimately, the goal is to identify potential targets for preventing or treating T1D by disrupting harmful immune responses.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating type I diabetes by targeting the immune mechanisms involved.
How similar studies have gone: Previous research has shown promising results in understanding autoimmune mechanisms in diabetes, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Miakicheva, Svetlana Dmitrievna — Weill Medical Coll of Cornell Univ
- Study coordinator: Miakicheva, Svetlana Dmitrievna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.