Investigating the genetic factors of behavioral traits in individuals with 3q29 deletion syndrome
Official title: The schizophrenia-associated 3q29 deletion: genetic architecture of behavioral phenotypes
Funded at Rutgers Biomedical and Health Sciences · NIH-11010796 · Data updated 2026-11-12
This study is looking at the challenges faced by people with 3q29 deletion syndrome, especially how their symptoms like autism, ADHD, and anxiety can vary based on their genetics and gender, and it's designed for individuals with this condition to participate from home easily.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project start | March 24, 2023 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $655,530 |
| NIH project number | 5R01MH126449-04 |
| Project ID | NIH-11010796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with 3q29 deletion syndrome, including those experiencing related behavioral and cognitive challenges.
✕Less likely to help
Patients without a diagnosis of 3q29 deletion syndrome or those not exhibiting significant behavioral or cognitive issues may not benefit from this research.
What this research studies
This research focuses on understanding the behavioral and cognitive challenges faced by individuals with 3q29 deletion syndrome, which is linked to a significantly increased risk of schizophrenia and other disorders. By evaluating 200 individuals with this genetic deletion, the study aims to identify how different genetic backgrounds and sex may influence the severity of symptoms such as autism, ADHD, and anxiety. A unique remote phenotyping approach will be used, allowing participants to engage in assessments from home, thus reducing barriers to participation. The goal is to better define the range of behavioral phenotypes associated with this condition and to understand the factors that contribute to their variability.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and management of behavioral and cognitive issues in individuals with 3q29 deletion syndrome.
How similar studies have gone: Previous research has shown success in using remote assessments for behavioral phenotyping, indicating that this approach is both feasible and effective.
Where this research is happening
-
Rutgers Biomedical and Health Sciences
Newark, United States Active
Researchers
- Principal investigator: Mulle, Jennifer Gladys — Rutgers Biomedical and Health Sciences
- Study coordinator: Mulle, Jennifer Gladys
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.