Investigating the effects of oxygen on organ injury during surgery
Oxygen and perioperative organ injury
This study is looking at how the amount of oxygen given during major surgery can affect the kidneys, brain, and heart, and it's for anyone who wants to understand how we can better protect these organs during surgery to help patients recover more safely.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Vanderbilt University Medical Center NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11096011 on NIH RePORTER |
What this research studies
This research focuses on understanding how oxygen levels during major surgery can lead to acute injuries in the kidneys, brain, and heart. The team is exploring the balance of oxygen administration, as both too little and too much oxygen can be harmful to patients. By studying the molecular pathways involved, they aim to identify new therapeutic targets that could help reduce organ injury. The ultimate goal is to develop better strategies for oxygen management in surgical settings to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for major surgeries who are at risk of acute kidney, brain, or heart injuries.
Not a fit: Patients undergoing minor procedures or those without risk factors for organ injury may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management of oxygen levels during surgery, reducing the risk of organ injuries and long-term complications for patients.
How similar studies have performed: Previous research has shown that managing oxygen levels can significantly impact patient outcomes, indicating that this approach has potential for success.
Where this research is happening
Nashville, United States
- Vanderbilt University Medical Center — Nashville, United States (Active)
Researchers
- Principal investigator: Billings, Frederic Tremaine — Vanderbilt University Medical Center
- Study coordinator: Billings, Frederic Tremaine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.