Investigating the effects of lung primary graft dysfunction after transplantation
The Clinical and Molecular Impacts of Lung Primary Graft Dysfunction
This study is looking at how problems that happen right after a lung transplant, called primary graft dysfunction, can affect long-term lung health and survival for people who have received a transplant, and it aims to find out more about the causes behind these issues by examining samples from the airways over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10892253 on NIH RePORTER |
What this research studies
This research focuses on understanding the complications that arise after lung transplantation, specifically primary graft dysfunction (PGD), which is a type of acute lung injury that occurs shortly after the procedure. The study aims to explore how severe PGD can lead to chronic lung allograft dysfunction (CLAD) and impact long-term survival in lung transplant recipients. By analyzing airway samples at different time points post-transplant, researchers will investigate the molecular mechanisms linking PGD to inflammation, infection, and lung function decline. This collaborative effort involves multiple institutions to enhance the understanding of these critical issues in lung transplantation.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have recently undergone lung transplantation and are at risk for primary graft dysfunction.
Not a fit: Patients who have not received a lung transplant or those with pre-existing severe lung conditions unrelated to transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for lung transplant recipients, potentially enhancing their long-term survival and quality of life.
How similar studies have performed: Previous research has shown that understanding the mechanisms of acute lung injury can lead to significant advancements in treatment approaches, indicating that this study builds on established knowledge in the field.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Mcdyer, John F — University of Pittsburgh at Pittsburgh
- Study coordinator: Mcdyer, John F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.