Investigating the effects of folic acid and B12 on brain development and behavior
Folic Acid, B12, and Neurodevelopmental Risk
This study is looking at how too much or too little folic acid and vitamin B12 can impact brain growth and behavior, especially in relation to conditions like autism, to help find ways to support healthy brain development in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project ID | NIH-11082367 on NIH RePORTER |
What this research studies
This research explores how both excessive and insufficient levels of folic acid and vitamin B12 affect brain development and behavior in a preclinical model. It focuses on understanding the structural defects in the cerebral cortex, which is crucial for various neurodevelopmental disorders, including autism spectrum disorders. By examining the biochemical and behavioral consequences of these micronutrient levels, the study aims to uncover the genetic and environmental factors that influence early brain development. This could lead to better preventive strategies for neurodevelopmental disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are pregnant individuals or those planning to conceive, as well as children with neurodevelopmental disorders.
Not a fit: Patients who are not pregnant or do not have children with neurodevelopmental disorders may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could provide insights into how to optimize folic acid and B12 supplementation to improve neurodevelopmental outcomes in children.
How similar studies have performed: Previous research has indicated that micronutrient levels can significantly impact neurodevelopment, suggesting that this approach may yield valuable insights.
Where this research is happening
Davis, United States
- University of California at Davis — Davis, United States (Active)
Researchers
- Principal investigator: Zarbalis, Konstantinos — University of California at Davis
- Study coordinator: Zarbalis, Konstantinos
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.